ea0090p406 | Pituitary and Neuroendocrinology | ECE2023
Guaraldi Federica
, Roncaroli Federico
, Villa Chiara
, Zoli Matteo
, Waqar Mueez
, Higham Claire
, Lally Imogen
, Baussart Bertrand
, Assie Guillaume
, Morandi Luca
, Mazzatenta Diego
, Asioli Sofia
Rationale and aim: A recent pangenomic study documented a subset of somatotroph mostly GNAS-wildtype PitNET/adenomas co-express steroidogenic factor 1 (SF1). Aim of our study was to investigate clinical and molecular features of a cohort of these tumour subtype. Study sample: We identified 20 cases of SF1-expressing somatotropinomas out of 173 (11.6%) operated via transsphenoidal endoscopic approach in 3 referral Pituitary Centers patients. Pre- and post...